Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
Completed · Not applicable · Has a placebo group
Conditions studied: Apnea, Sleep, Chronic Fatigue Syndrome
In brief
The purpose of this study is to determine any sleep disordered breathing in veterans with Gulf War Syndrome (GWS) and compare it to healthy normal asymptomatic Gulf War veterans. This study will also determine the effect of treatment with continuous positive airway pressure on veterans with Gulf War Syndrome. 1. The investigators hypothesize that sleep complaints (insomnia, un-refreshing sleep and daytime fatigue) among GWS patients are related to increased sleep fragmentation secondary to the presence of sleep disordered breathing in GWS patients. 2. The investigators hypothesize that increased collapsibility of the upper airway during sleep with the development of inspiratory flow limitation (IFL) and sleep disordered breathing causes the increased sleep fragmentation in GWS patients. 3. The investigators hypothesize that correction of IFL and sleep disordered breathing in GWS patients will result in an improvement of their sleep quality resulting in an improvement of their sleep complaints and other functional symptoms.
Key facts
- Study ID
- NCT00252629
- Run by
- US Department of Veterans Affairs
- People needed
- 29
- Starts
- 2005-11-01
- Expected to finish
- 2010-11-01
- Last updated by the study team
- 2014-12-11
Who can join
Age: 32 and older, up to 52. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- First Gulf War veterans with and without the syndrome
- Males
- Between 32 and 52 years of age
- No history of current alcoholism nor opiate use
- No history of current active depression nor post-traumatic stress disorder (PTSD)
You may not qualify if…
- Females
- History of active alcoholism or opiate drug use
- History of active depression and PTSD
Where it is running
- VA Medical Center, Northport — Northport, New York, United States
Full record on ClinicalTrials.gov
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