Timing of Target Enteral Feeding in the Mechanically Ventilated Patient
Completed · Phase 2/Phase 3
Conditions studied: Acute Respiratory Failure
In brief
This study tests the hypothesis that initial trophic enteral feedings will increase the time alive and free of mechanical ventilation as compared to initial goal enteral feedings in patients who are mechanically ventilated.
Key facts
- Study ID
- NCT00252616
- Run by
- Vanderbilt University
- People needed
- 200
- Starts
- 2003-09-01
- Expected to finish
- 2009-10-01
- Last updated by the study team
- 2013-12-17
Who can join
Age: 13 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- More than 48 hours elapsed since both inclusion criteria met.
- Patient, legal representative, or physician refuses consent or is unavailable to provide consent.
- Patient, legal representative, or physician not committed to full support (Exception: A patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest).
- Presence of malignant or irreversible condition and estimated 28 day mortality greater than 50%.
- Severe or refractory shock.
- Moribund patients not expected to survive 24 hours from start of enteral feeding (as determined by primary medical team).
- Child-Pugh score greater than 10.
- Presence of partial or complete mechanical bowel obstruction, or ischemia, or infarction.
- Current TPN use or intent to use TPN within 7 days.
- Severe malnutrition with BMI less than 18.5 and/or loss of more than 30% total body weight in the previous 6 months.
- Neuromuscular disease impairing the ability to ventilate spontaneously.
- Laparotomy expected within 7 days.
- Unable to raise head of bed 45°.
- greater than 30% total body surface area burns.
- Absence of GI tract/short bowel syndrome - defined as entire length of small bowel totaling 4 feet or less.
- Presence of high-output (> 500 cc/day) enterocutaneous fistula.
- Age less than 13 years
- Allergy to enteral formula
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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