Genetic Predictors of Lithium Response in Bipolar Disorder
Completed
Conditions studied: Bipolar Disorder
In brief
The purpose of this study is to identify genetic predictors of lithium response in bipolar disorder.
Key facts
- Study ID
- NCT00252577
- Run by
- VA Office of Research and Development
- People needed
- 130
- Starts
- 2005-10-01
- Expected to finish
- 2016-05-01
- Last updated by the study team
- 2020-01-29
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Are 18 years of age or older;
- Have a diagnosis of Bipolar Affective Disorder, I or II;
- Have no contraindications, allergies, or previous adverse events or treatment failures with lithium;
- Women who are not currently pregnant and are willing and able to use birth control;
- Are clinically appropriate to treat with lithium.
You may not qualify if…
- DSM-IV Axis I Diagnosis: other primary comorbid axis I disorders such as: schizophrenia, schizoaffective disorder, delusional disorder;
- Alcohol or Substance Dependence: meets criteria for dependence within past 3 months;
- Unstable Medial Conditions: Life threatening or unstable medical condition that require active adjustment of medications by medical history; or
- Medical Conditions: concomitant medical condition that would preclude the use of lithium (i.e.: renal failure, head trauma with loss of consciousness, or clinically significant cardiac, renal, hepatic, neoplastic, or cardiovascular disease);
- Concomitant treatment with the following medications (during maintenance Phase): antipsychotics, antidepressants, antianxiety agent with the exception of benzodiazepines, to be used if needed for anxiety or insomnia, not to exceed 10 doses/week, or mood stabilizers with the exception of lithium; and
- Active suicidal or homicidal ideations as elicited in the interviews.
- Stable and doing well on a mood stabilizer other than lithium.
Where it is running
- VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States
Full record on ClinicalTrials.gov
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