Genetic and Biochemical Markers of Interferon-Induced Depression.

Completed

Conditions studied: Depression

In brief

The purpose of this study is to identify predictors and associated biochemical markers of interferon-induced depression. It is hypothesized that genetic variation in genes related to the serotonergic system may predict vulnerability to interferon-induced depression.

Key facts

Study ID

NCT00252538

Run by

US Department of Veterans Affairs

People needed

133

Starts

2006-04-01

Expected to finish

2009-09-01

Last updated by the study team

2014-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Serum positive for hepatitis C
• Age 18 or older
• Not pregnant and using adequate contraception
• Hepatologist-determined patient is a candidate for interferon therapy
• Written/signed informed consent specific for this protocol has been obtained prior to entry

You may not qualify if…

• Diagnosis of active: depression, psychotic symptoms, or bipolar disorder (or history of bipolar disorder) during the previous 3 months
• On antidepressant medications for any reason
• Currently abusing any substances such as alcohol or intravenous drugs, or having abused in the past 6 months.

Where it is running

• VA Medical Center, Long Beach — Long Beach, California, United States
• VA Medical Center, Minneapolis — Minneapolis, Minnesota, United States
• VA Medical Center, Portland — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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