PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram
Completed · Phase 1
Conditions studied: Dosimetry, Healthy
In brief
The purpose of this study is to measure a particular protein in the brain called the phosphodiesterase by using the imaging techniques of positron emission tomography (PET) and magnetic resonance imaging (MRI). ...
Key facts
- Study ID
- NCT00250172
- Run by
- National Institute of Mental Health (NIMH)
- People needed
- 26
- Starts
- 2005-10-31
- Expected to finish
- 2009-02-05
- Last updated by the study team
- 2019-12-16
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- PART 1 (WHOLE BODY IMAGING STUDIES):
- Current psychiatric disease, substance abuse or severe systemic disease based on history and physical exam, poor vision or hearing.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure including that from this protocol would exceed a half of the annual limits. Because human dosimetry of (R)-[(11)C]rolipram has been estimated using rhesus monkeys, the total exposure including that from the (R)-[(11)C]rolipram whole body imaging study will be limited to a half of the RSC guidelines.
- Pregnancy and breast feeding.
- Positive HIV test.
- Positive urine drug screen.
- PART 2 (TEST RETEST BRAIN IMAGING STUDIES):
- Current psychiatric disease, substance abuse or severe systemic disease based on history and physical exam, poor vision or hearing.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual limits. Results of part 1 will be used to calculate total radiation exposure within a year.
- Pregnancy and breast feeding.
- Claustrophobia.
- Presence of ferromagnetic metal in the body or heart pacemaker.
- Positive HIV test.
- A history of brain disease.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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