Study of PET Scans and Serotonin in Hot Flashes Treatment

Stopped early · Not applicable

Conditions studied: Hot Flashes

In brief

The purpose of this study is to determine in a preliminary manner whether successful therapy of hot flashes can be associated with changes in the serotonin transporter in the brain. The serotonin transporter is important in delivering serotonin into certain portions of the brains (serotonin is a chemical that is important in the control of body temperature, mood, sleep, and other functions).

Key facts

Study ID

NCT00249847

Run by

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

People needed

5

Starts

2005-10-01

Expected to finish

2008-04-01

Last updated by the study team

2014-10-02

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Postmenopausal women
• 7 or more hot flashes per day for at least 3 months
• Must be able to undergo magnetic resonance (MR) and PET imaging
• Must be able to receive either paroxetine or estrogen

You may not qualify if…

• No treatment with hormone therapy or other medications that affect estrogen within the past 3 months
• No evidence of a currently active cancer

Where it is running

• Johns Hopkins University School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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