Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals
Completed · Phase 2
Conditions studied: Marijuana Abuse
In brief
Recent research has identified the following withdrawal symptoms to be associated with abruptly stopping marijuana use: anxiety, irritability, bodily aches and pains, and difficulty sleeping. These symptoms resemble those of both depression and nicotine withdrawal, suggesting that a similar treatment drug may be useful. This study will evaluate the effectiveness of two antidepressant drugs, bupropion and nefazodone, in reducing withdrawal symptoms in marijuana dependent individuals.
Key facts
- Study ID
- NCT00249509
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 132
- Starts
- 2000-09-01
- Expected to finish
- 2004-09-01
- Last updated by the study team
- 2017-01-16
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Meets DSM-IV criteria for current marijuana dependence
- Uses at least 5 marijuana joints per week
- Currently seeking treatment for marijuana dependence
- Used marijuana in a maladaptive pattern in the 6 months prior to study entry
You may not qualify if…
- History of seizures or unexplained loss of consciousness
- Significant and unstable psychiatric condition (e.g., schizophrenia, bipolar disorder)
- Chronic organic mental disorder
- Dependent on any substances of abuse other than marijuana
- Currently at significant suicidal risk
- Unstable physical disorder that may represent a severe untreated condition, such as hypertension (blood pressure greater than 150/90), elevated transaminase levels, or unstable diabetes
- Current or suspected coronary vascular disease
- Has taken a monoamine oxidase inhibitor in the 2 weeks prior to study entry
- Currently taking terfenedine, cisapride, astemizole, or pimozide
- History of an allergic reaction to bupropion or nefazodone
- If female, pregnant, breastfeeding, or unwilling to use an adequate method of contraception for the duration of the study
Where it is running
- New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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