Assessing Mucociliary Clearance and Airway Liquid Volume in the CF Airway

Completed · Not applicable

Conditions studied: Cystic Fibrosis

In brief

The objective of this study is to determine the effect of airway surface liquid (ASL) volume on mucociliary clearance in cystic fibrosis (CF). A two-isotope nuclear medicine technique will be utilized. This pilot trial will include the imaging of n=7 CF subjects and n=7 healthy subjects. The trial will include one study visit per subject that will take approximately 3 hours. Hypothesis: The simultaneous imaging of both a "floating" and a "penetrating" radioisotope tag will allow the relative effect of airway surface liquid volume on mucociliary clearance to be determined when evaluated in CF and normal subjects.

Key facts

Study ID

NCT00248755

Run by

University of Pittsburgh

People needed

14

Starts

2005-11-01

Expected to finish

2006-08-01

Last updated by the study team

2017-07-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 18 years
• Diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms (CF subjects only)
• Clinically stable as determined by the investigator (pulmonologist)

You may not qualify if…

• Reactive airways disease
• Tobacco smokers
• Positive urine pregnancy test on the day of testing
• FEV1p value of < 30%
• SaO2 < 92%, or if they require supplemental oxygen.
• Subjects receiving other radioisotope treatments within the last 2 weeks will be excluded.
• Normal subjects with any history of lung disease will be excluded.
• Women currently breastfeeding an infant.

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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