Short-Term Effects of Medicinal Cannabis Therapy on Spasticity in Multiple Sclerosis

Completed · Phase 1/Phase 2

Conditions studied: Multiple Sclerosis

In brief

The purpose of this study is to determine whether or not smoked marijuana improves spasticity in patients with multiple sclerosis.

Key facts

Study ID

NCT00248378

Run by

Center for Medicinal Cannabis Research

People needed

30

Starts

2001-09-01

Expected to finish

2005-03-01

Last updated by the study team

2006-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically definite or probable, laboratory-supported MS
• Complaints of spasticity and at least moderate increase in tone as evidenced by a score of >= 2 on the Modified Ashworth Scale at either the elbow, hip, or knee
• If on disease-modifying therapy ("ABC"), have been on a stable dose for at least six months
• Fluent in English
• If not cannabis-naive, must refrain from smoking cannabis for two weeks prior to screening (confirmed by urinalysis)
• If on either lioresal (Baclofen) or tizanadine (Zanaflex), have been on a stable dose for at least three months
• >=18 years of age

You may not qualify if…

• Axis I psychiatric disorder especially depression or significant neurological disease other than MS as determined by the PI
• Recent history of active substance abuse defined as daily use for at least 14 days within the past month
• Drug use restrictions, eg, subjects on probation or parole, employment involving high risk to themselves and/or the public (airline pilot, bus driver, etc.)
• Any unstable medical health problem
• Any known pulmonary disorders, including tuberculosis, asthma, or COPD
• Pregnant or nursing
• Require benzodiazepines to control spasticity
• Require high doses of analgesic medications on a daily basis

Where it is running

• UC San Diego Medical Center — San Diego, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.