The Genetic Basis of Atrial Fibrillation (AF)

Completed

Conditions studied: Atrial Fibrillation

In brief

The investigators' goal with this research is to: 1. Establish a clinical database and a DNA bank for 1000 individuals with AF and 1000 individuals without AF. 2. Directly test the hypothesis that known functional polymorphisms in the coding sequences and the promoter regions of cardiac genes (ion channels and genes known to affect survival in the setting of left ventricular dysfunction) predispose individuals to AF. Over the past decade, advancing techniques and technologies for gene characterization have yielded significant clues as to the molecular mechanism of certain human heart rhythm disorders. The role of ion channel polymorphisms in subjects with AF is unknown. Similarly, it is also not known whether polymorphisms in other genes have an impact on the risk of AF. The ability to characterize genomic "at-risk" profiles would have many potential benefits for patient care. Paramount among these is: 1. Increased oversight or intervention of at-risk subjects, which might prevent unnecessary morbidity and mortality due to AF. 2. Further insight into the pathogenesis of AF, which may lead to preventative or curative therapies.

Key facts

Study ID
NCT00248326
Run by
University of Pittsburgh
People needed
50
Starts
2005-01-01
Expected to finish
2010-01-01
Last updated by the study team
2016-01-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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