Hangover, Congeners, Sleep and Occupational Performance

Completed · Phase 2

Conditions studied: Sleep, Neurobehavioral Manifestations

In brief

The objective is to investigate residual effects of heavy drinking, with or without hangover symptoms. The primary aim is to test several hypotheses about residual effects of heavy drinking. Hypotheses about how heavy drinking affects next-day performance include direct physiological effects of alcohol, alcohol withdrawal effects, and non-ethanol effects, such as congeners, or family history of alcohol problems. The investigators will test the following hypotheses: 1. relative to placebo, heavy drinking will degrade next-day performance, and this relationship will be mediated in full or in part by quality of sleep; 2. a high congener alcoholic beverage will affect performance to a greater degree than a low congener beverage and this relationship will be mediated by severity of hangover symptoms.

Key facts

Study ID

NCT00247585

Run by

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

People needed

140

Starts

2003-09-01

Expected to finish

2006-06-01

Last updated by the study team

2006-12-06

Who can join

Age: 21 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 21-30
• Currently enrolled or have completed college/university
• Have had 5 or more drinks (4 if female) in the last 30 days
• Score less than a 5 on the Short Michigan Alcohol Screening Test (SMAST)
• No self-reported history of counseling or treatment for substance abuse
• Not taking any medication contraindicated for alcohol use or that disrupts sleep
• Doesn't have a health condition contraindicated for alcohol use
• Has not been diagnosed with a primary sleep disorder
• Has not been diagnosed with a mental health disorder
• Not currently working night shifts at a job
• Not routinely taking medications that affect sleep
• No evidence of extreme morningness or eveningness as assessed by questionnaire
• Not a regular smoker

You may not qualify if…

• Less than age 21 and greater than age 30
• Not currently enrolled or has not completed college/university
• Hasn't had 5 or more drinks (4 if female) in the last 30 days (not a regular drinker)
• Score greater than or equal to 5 on the Short Michigan Alcohol Screening Test (SMAST)
• Self-reported history of counseling or treatment for substance abuse
• Taking any medication contraindicated for alcohol use or that disrupts sleep
• Has a health condition contraindicated for alcohol use
• Has been diagnosed with a primary sleep disorder
• Has been diagnosed with a mental health disorder
• Currently working night shifts at a job
• Routinely taking medications that affect sleep
• Evidence of extreme morningness or eveningness as assessed by questionnaire
• Is a regular smoker
• Not a regular drinker
• Is pregnant or nursing

Where it is running

• General Clinical Research Center, Boston University School of Public Health/Boston Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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