Ischemic Preconditioning of Liver in Cadaver Donors

Completed · Not applicable

Conditions studied: Liver Cirrhosis, Liver Disease

In brief

The long-term goals of this proposal are to develop clinical protocols of donor preconditioning to improve liver graft function and ameliorate complications of poor graft function after liver transplantation. Achievement of these objectives would improve liver recipient outcomes, increase utilization of livers and alleviate the current critical shortage of livers for transplantation. More stringent liver donor selection intended to decrease the complications of poor graft function conflicts directly with efforts to maximize the use of donor livers. Ischemic preconditioning (IPC) of liver attenuates hepatic ischemia reperfusion injury (IRI) in animals. Preliminary data show hepatic IPC effectively decreases IRI following hepatic resection in humans. The specific aims of this project are: AIM 1: To test the hypothesis that 10 minutes of hepatic ischemic preconditioning in deceased donors would improve liver graft function and decrease injury in the early post transplant period. AIM 2: To test the hypothesis that ischemic preconditioning of deceased donor livers would decrease systemic inflammatory response in liver recipients in the early post transplant period. AIM 3: To examine whether ischemic preconditioning of deceased donor livers decreases early post transplant pulmonary edema and acute rejection and shortens hospital stay.

Key facts

Study ID

NCT00245830

Run by

University of Medicine and Dentistry of New Jersey

People needed

100

Starts

2003-10-01

Expected to finish

2007-03-01

Last updated by the study team

2015-01-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Deceased donor livers allocated to adult (> 18 years of age) recipients at the research site.

You may not qualify if…

• Deceased donor livers allocated to recipients at centers other than the research site.
• Deceased donor livers allocated to recipients < 18 years of age at the research site.
• Non-heart beating donors
• Deceased liver and small intestine donors
• Live liver donors.

Where it is running

• University Hospital — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.