Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.

Completed · Not applicable

Conditions studied: Colon Cancer, Polyp, Adenoma

In brief

The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy. Patients will be randomized to either conventional colonoscopy or chromocolonoscopy, where the entire colon will be sprayed with indigocarmine dye and examined in the usual manner. The primary outcome will be the total number of adenomas detected, with special attention to the subgroup of flat and depressed lesions. To promote the generalizability of the results, neoplasms will be described according to standard Western and Japanese classification schemes.

Key facts

Study ID

NCT00245492

Run by

Indiana University

People needed

792

Starts

2006-05-01

Expected to finish

2008-12-01

Last updated by the study team

2009-01-28

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients undergoing screening colonoscopy

You may not qualify if…

• Age < 50
• Prior colon resection
• Inflammatory bowel disease
• Prior colonoscopy or sigmoidoscopy
• More than one first-degree relative with colon cancer

Where it is running

• Indiana University — Indianapolis, Indiana, United States
• Roudebush VA Medical Center — Indianapolis, Indiana, United States
• SUNY Stony Brook — Stony Brook, New York, United States

Full record on ClinicalTrials.gov

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