Predictor of Advanced Subclinical Atherosclerosis

Completed

Conditions studied: Coronary Artery Disease

In brief

Evaluation of skin cholesterol for cardiovascular risk assessment in asymptomatic individuals at low, intermediate, or high risk based on Framingham Global Risk estimates. Carotid intima-media thickness (IMT), a surrogate marker for atherosclerotic burden, that independently predicts the occurrence of heart attack and stroke, will be the "gold standard" comparator. Hypothesis: Skin cholesterol, as measured by two non-invasive tests, correlates with CAD, as measured by CIMT in this population.

Key facts

Study ID

NCT00245284

Run by

PreMD

People needed

600

Starts

2005-09-01

Expected to finish

2006-05-01

Last updated by the study team

2006-06-06

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Informed written consent from the subject prior to testing.
• Males or females 40-80 years of age

You may not qualify if…

• Subjects taking cholesterol-lowering medications
• Known hepatitis
• Known pregnancy
• Skin disease on either hand (e.g. eczema psoriasis, rash or broken skin)
• Known CAD (previous myocardial infarction, coronary revascularization procedure), cerebrovascular disease (previous stroke, transient ischemic attack, or carotid revascularization procedure), or peripheral arterial disease(claudication or previous revascularization procedure)

Where it is running

• Radiant Research — Chicago, Illinois, United States
• University of Chicago — Chicago, Illinois, United States
• Johns Hopkins Hospital — Baltimore, Maryland, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• University od Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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