Possible Relation of Toll-Like Receptors and Nitric Oxide to Chronic Lung Disease

Completed

Conditions studied: Lung Diseases

In brief

The first objective of this study is to determine if increased expression of one or more members of the toll-like receptor (TLR) family of receptors that are found on inflammatory cells (present in the airway) precede development of chronic lung disease (CLD) of prematurity. The study will also determine if there is a significant correlation between TLRs and the severity of CLD. The second objective of this study is to determine the impact of c-administration of inhaled nitric oxide (INO) on TLR expression in infants at risk of developing CLD or with early CLD.

Key facts

Study ID

NCT00245167

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

120

Starts

2002-01-01

Expected to finish

2006-05-01

Last updated by the study team

2016-07-29

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Birth weight less than 1250 gm
• Requiring assisted ventilation

You may not qualify if…

• Moribund condition
• Major pulmonary or cardiovascular associated anomaly

Where it is running

• Children's Mercy Hospital & Clinic — Kansas City, Missouri, United States
• Children's Hospital and Regional Medical Center (Seattle) — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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