Examining the Role of Negative Emotional States on Sedative Drug Use in Individuals With Post-Traumatic Stress Disorder
Completed
Conditions studied: Stress Disorders, Post-Traumatic
In brief
Post-traumatic stress disorder (PTSD) is a serious illness, in which individuals often experience anxiety and stress. Some individuals with PTSD use drugs to alleviate emotional distress. This study will examine the role that negative emotional states play in sedative drug use among individuals with PTSD.
Key facts
- Study ID
- NCT00244335
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 39
- Starts
- 2000-10-01
- Expected to finish
- 2008-07-01
- Last updated by the study team
- 2017-01-10
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of PTSD with anxiety symptoms, as determined by a score greater than 14 on the Hamilton Anxiety Rating Scale, or a score greater than 18 on the Profile of Mood States-Tension Anxiety Rating Scale
- Experiences frequent and intense PTSD symptoms
- Able to spend 6 hours at a time in the research laboratory
- If a trauma control participant, must have experienced a trauma that meets criterion A for PTSD, but has never developed PTSD
- Willing to use contraception throughout the study
You may not qualify if…
- Females who meet DSM-IV diagnostic criteria for premenstrual dysphoric disorder
- Females who report premenstrual distress that motivates them to use alcohol for relief
- History of bipolar affective disorder, any psychotic disorder, current major depressive episode, or current primary non-PTSD anxiety disorder (individuals with Axis II diagnoses will not be excluded)
- Currently enrolled in psychodynamic or cognitive-behavioral therapy
- Current unstable medical illness
- Current medical illness treated with psychoactive drugs (e.g., beta blockers)
- Current medical illness with complicating psychiatric symptoms (e.g., thyroid disease)
- Requires use of certain medications
- Current or past history of illicit substance dependence, other than past marijuana abuse or dependence
- History of tobacco dependence
- Failure to provide a drug-free urine sample prior to study entry
- Smokes more than one pack of cigarettes per day or drinks beverages totaling more than 500 mg of caffeine per day
- Pregnant
Where it is running
- University of Texas Health Science Center, San Antonio — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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