Effects of Nutritional Supplementation on Protein and Energy Homeostasis in Malnourished Chronic Hemodialysis Patients

Completed · Phase 2

Conditions studied: End Stage Renal Disease

In brief

The goal of this study is to evaluate the metabolic effects of concomitant use of three consecutive doses of recombinant human growth hormone over three days and exercise during continuous nutrient infusion in chronic hemodialysis patients. We would also like to evaluate the metabolic effects of nutritional supplementation alone without the additional anabolic strategies.

Key facts

Study ID

NCT00244075

Run by

Vanderbilt University

People needed

46

Starts

1998-07-01

Expected to finish

2006-08-01

Last updated by the study team

2015-05-25

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• On hemodialysis for more than 6 months, on a thrice weekly hemodialysis program;
• Adequately dialyzed (Kt/V > 1.4).

You may not qualify if…

• Patients unable to perform exercise.
• Pregnant women.
• Severe unstable underlying disease besides commonly associated with ESRD. Cardiac patients that are stable will be included.
• Patients hospitalized within the last month prior to the study.
• Patients with recirculation detected on the AV graft.
• Patients receiving steroids and/or other immunosuppressive agents

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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