Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Completed · Phase 1

Conditions studied: Aneurysms, Arteriovenous Malformations

In brief

The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.

Key facts

Study ID

NCT00243893

Run by

University of California, San Francisco

People needed

26

Starts

2004-07-01

Expected to finish

2008-10-01

Last updated by the study team

2013-10-09

Who can join

Age: 13 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Giant aneurysms or brain arteriovenous malformations (BAVM)
• Female patients of child bearing age using effective birth control, males
• Creatinine no greater than 2.0 mg/dl
• ALT no greater than 2 times upper limit of control

You may not qualify if…

• Unstable medical illness
• Contraindications to Tetracycline
• History of vestibular disease, (except benign positional vertigo)
• Prior tetracycline use within 2 mos of baseline visit.
• History of noncompliance with treatment or other protocols
• History of systemic lupus
• Patients not eligible for MRI

Where it is running

• University of California — San Francisco, California, United States

Full record on ClinicalTrials.gov

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