Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Recruiting now

Conditions studied: Congenital Heart Disease, Tetralogy of Fallot

In brief

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.

Key facts

Study ID

NCT00243776

Run by

Emory University

People needed

600

Starts

2005-04-01

Expected to finish

2027-12-01

Last updated by the study team

2026-05-06

Who can join

Age: any, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing cardiopulmonary bypass surgery
• Patients undergoing surgery for repair of congenital heart disease such as ventricular septal defect or defective mitral or aortic valves.

You may not qualify if…

• Prior cardiac surgery
• History of atrial fibrillation or other atrial arrhythmias prior to operation
• History of heart failure

Where it is running

• Emory University School of Medicine — Atlanta, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.