Serp-1 for the Treatment of Acute Coronary Syndrome
Stopped early · Phase 2
Conditions studied: Unstable Angina, Coronary Atherosclerosis, Coronary Restenosis
In brief
Males and females aged 18-80 years who present with ACS (unstable angina and non ST-elevation MI) defined as one or more episodes of angina lasting at least 5 minutes in the last 24 hours before admission and greater than 0.05 mV of presumed new ST-segment depression in at least 2 contiguous ECG leads OR, angina and per confirmatory angiogram, has been scheduled for percutaneous coronary angioplasty. The primary objective of this study is to evaluate the safety of Serp-1 injection when administered in 3 daily doses to patients undergoing conventional therapy for Acute Coronary Syndrome (ACS) requiring early intervention.
Key facts
- Study ID
- NCT00243308
- Run by
- Viron Therapeutics Inc
- People needed
- 72
- Starts
- 2005-10-01
- Expected to finish
- 2008-12-01
- Last updated by the study team
- 2009-02-06
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Established diagnosis of unstable angina or NSTEMI with one or more episodes of angina in the 24 hours before hospital admission
- Scheduled for PCI
You may not qualify if…
- CABG within 6 months
- Acute ST elevation, eligible for thrombolysis on initial examination
- Coronary lesions with total thrombotic occlusions
- Current immunosuppressant therapy
Where it is running
- Washington Hospital Center — Washington D.C., District of Columbia, United States
- University of Florida — Gainesville, Florida, United States
- Spectrum Health — Grand Rapids, Michigan, United States
- Victoria Heart Institute — Vicotria, British Columbia, Canada
- Foothills Medical Center — Calgary, Ontario, Canada
- London Health Sciences Centre — London, Ontario, Canada
- University of Ottawa Heart Institute — Ottawa, Ontario, Canada
- Montreal Heart Institute — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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