Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI

Completed · Not applicable · Has a placebo group

Conditions studied: Facial Neuropathy

In brief

The aim of this project is to evaluate the effects of the anticonvulsant drug lamotrigine (trade name Lamictal) on neuropathic facial pain or neuralgia using functional magnetic resonance imaging (fMRI).

Key facts

Study ID

NCT00243152

Run by

Pain and Analgesia Imaging and Neuroscience Group

People needed

6

Starts

2005-10-01

Expected to finish

2008-07-01

Last updated by the study team

2018-12-07

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-60 years of age
• Right-handed non-smokers
• Diagnosed with facial pain
• Continuous pain for more than 3 months
• Spontaneous pain greater than 3 of 10
• Allodynia to brush greater than 5 of 10

You may not qualify if…

• Medications
• Depression
• Significant medical problems
• Claustrophobia
• Abnormal EKG
• Significant drug or alcohol history
• Positive drug screen
• Weight greater than 285 lbs
• History of allergy to anticonvulsants
• Tattoos with metallic ink on upper body
• Any neurostimulator devices, or metal cochlear, ocular, or cardiac implants or other metal near vital areas
• Exposure to shrapnel or metal filings
• Other metallic surgical hardware

Where it is running

• McLean Hospital Neuroimaging Center, 115 Mill Street — Belmont, Massachusetts, United States

Full record on ClinicalTrials.gov

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