S0509 - AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery
Completed · Phase 2
Conditions studied: Advanced Malignant Mesothelioma, Epithelial Mesothelioma, Recurrent Malignant Mesothelioma, Sarcomatous Mesothelioma
In brief
This phase II trial is study how well AZD2171 works in treating patients with malignant pleural mesothelioma that cannot be removed by surgery. AZD2171 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor
Key facts
- Study ID
- NCT00243074
- Run by
- National Cancer Institute (NCI)
- People needed
- 54
- Starts
- 2005-11-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2018-01-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed epithelial, sarcomatous, or biphasic malignant pleural mesothelioma
- Unresectable disease
- Residual disease after prior cytoreductive surgery allowed
- Measurable disease by CT scan or MRI
- Prior treatment with platinum-based chemotherapy required
- No known CNS metastasis
- Performance status
- Zubrod 0-2
- WBC >= 3,000/mm\^3
- Absolute neutrophil count >= 1,500/mm\^3
- Platelet count >= 100,000/mm\^3
- AST or ALT =< 1.5 times upper limit of normal (ULN)
- Bilirubin normal
- Creatinine =< 1.5 times ULN OR
- Creatinine clearance >= 50 mL/min
- Proteinuria =< 1+ by 2 consecutive dipstick tests taken >= 1 week apart
- No history of familial long QT syndrome
- Mean QTc =< 470 msec
- Systolic BP =< 150 mm Hg AND diastolic BP =< 100 mm Hg
- Must have New York Heart Association class I or II disease
- Class II must be controlled with treatment
- Able to swallow and/or receive enteral medications via gastrostomy feeding tube
- Not requiring IV alimentation
- No active peptic ulcer
- No intractable nausea or vomiting
Where it is running
- Southwest Oncology Group — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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