Prospective Investigation of Pulmonary Embolism Diagnosis III
Completed
Conditions studied: Lung Diseases, Pulmonary Embolism
In brief
The purpose of this study is to determine the diagnostic accuracy of gadolinium-enhanced magnetic resonance angiography (Gd-MRA) of the pulmonary arteries in combination with magnetic resonance venography (MRV) of the veins of the thighs in patients with clinically suspected acute pulmonary embolism (PE).
Key facts
- Study ID
- NCT00241826
- Run by
- George Washington University
- People needed
- 1256
- Starts
- 2006-04-01
- Expected to finish
- 2009-04-01
- Last updated by the study team
- 2013-08-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute PE of diagnostic concern
- Informed consent
- Willing to undergo Gd-MRA/MRV
You may not qualify if…
- Any implanted ferromagnetic foreign body, including a ferromagnetic cerebral aneurysm clip or implanted electrical device/pump
- Dependency on a continuous connection to an external electrical device/pump (e.g., pacemaker, internal defibrillator, cochlear implant, nerve or bone stimulator implant, ICU appliance) and cardiac pacing wires
- Severe claustrophobia
- Severe shaking
- Inability to lie still for 30 minutes
- Pregnancy and nursing mothers
- Serum creatinine levels within range of normal at local center
- Sickle cell anemia, other hemoglobinopathies, and other hemolytic anemias
- Critical illness, shock or hypotension, hemodynamic instability, ventilatory support, chronic anticoagulation, inferior vena cava filter
- Documented episodes of ventricular fibrillation or sustained ventricular tachycardia within the past 24 hours
- Myocardial infarction within the past month
- History of allergy to gadolinium-containing contrast agents or to iodinated contrast media
- Current symptomatic asthma
- Clinical evidence of venous thrombosis of the upper extremity
- Prisoners
- Institutionalized or mentally handicapped patients
- Too large to fit in MRI unit
Where it is running
- Emory University — Atlanta, Georgia, United States
- Divison of Lung Diseases, NHLBI — Bethesda, Maryland, United States
- Data Coordinating Center — Rockville, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- University of Michigan Medical Center — Ann Arbor, Michigan, United States
- St. Joseph Mercy-Oakland — Pontiac, Michigan, United States
- Washington University Medical Center — St Louis, Missouri, United States
- NYU Medical Center — New York, New York, United States
- Foothills Hospital — Calgary, Alberta, Canada
Full record on ClinicalTrials.gov
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