Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder

Completed · Phase 4

Conditions studied: Tourette's Syndrome, Tic Disorders

In brief

The purpose of this study is to determine if Abilify will reduce tics (repetitive, uncontrollable movements or vocalizations) in children and adolescents ages 7-18 with Tourette's Disorder (TD) or a chronic motor tic disorder (either repetitive, uncontrollable movements or vocalizations).

Key facts

Study ID

NCT00241176

Run by

NYU Langone Health

People needed

11

Starts

2005-09-01

Expected to finish

2010-02-01

Last updated by the study team

2016-12-09

Who can join

Age: 7 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Child or adolescent must be 7 to 18 years of age (inclusive) when informed consent is obtained.
• Must meet full criteria for Tourette's Disorder or chronic motor tic disorder.
• Must have failed to respond to an adequate trial, as determined by the investigator, of clonidine, guanfacine, or neuroleptic medication in the past.
• Tics are causing significant distress or impairment, as determined by parent/subject and principal investigator, on current treatment regimen.
• Laboratory results, including serum chemistries, hematology, and urinalysis, must show no significant abnormalities (significant is defined as laboratory values requiring acute medical intervention).
• Must be able to swallow pills.
• Must be of normal intelligence in the judgment of the investigator.
• Must possess an educational level, degree of understanding and command of the English language to enable them to communicate suitably with the investigator and study coordinator, and to understand the nature of the study.
• Subjects and their legal representatives must be considered reliable.
• Written informed consent of parents and subjects (ages 18 and above) and assent of subjects ages 7-17 will be obtained.

You may not qualify if…

• Organic brain disease, for example, traumatic brain injury residua.
• Mental retardation as defined by the DSM-IV-TR.
• A history of seizure disorder (other than febrile seizure).
• A history of Sydenham's Chorea.
• Autism, schizophrenia, other psychotic disorder, or bipolar disorder.
• A primary diagnosis of a major mood disorder that requires ongoing psychiatric treatment.
• A neurological disorder other than a tic disorder.
• A major medical illness.
• Females who are of child bearing age who are unwilling to use birth control or who are pregnant, as determined by serum pregnancy test at baseline assessment, or lactating.
• Have a past or current history of substance dependence and/or a current history of substance abuse or who fail baseline toxic screen.
• Have any clinically significant abnormal laboratory result at baseline screening including EKG, or blood tests.
• Have a history of ongoing or previously undisclosed child abuse (risk of removal from home would not allow for consistent caretaker ratings).

Where it is running

• NYU Child Study Center — New York, New York, United States

Full record on ClinicalTrials.gov

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