Nitric Oxide Administration for Acute Respiratory Distress Syndrome

Completed · Phase 3

Conditions studied: Acute Respiratory Distress Syndrome

In brief

This research project is an open-label, randomized study for the use of Nitric Oxide in pediatric patients with acute respiratory distress syndrome (ARDS). The study examines whether nitric oxide (NO) treatment impacts the the P:F ratio (arterial partial pressure of oxygen (PaO2) divided by fraction of inspired oxygen (FiO2) in patients with ARDS. The goal of the study is to evaluate whether the order of NO therapy will have any effect on response, and evaluate the characteristics of patients who respond to NO compared to those who do not.

Key facts

Study ID

NCT00240487

Run by

Children's Hospital of Philadelphia

People needed

52

Starts

2000-09-01

Expected to finish

2008-09-01

Last updated by the study team

2015-04-24

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is intubated and mechanically ventilated in the Pediatric Intensive Care Unit with a PaO2/FiO2 ratio less than or equal to 100, FiO2 greater than or equal to 0.60, PEEP greater than or equal to 10, and a Murray score greater than or equal to 2.5.

You may not qualify if…

• Neonates (1 week to 28 days) and/or patients on extracorporeal membrane oxygenation

Where it is running

• The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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