A Study to Evaluate Combining Metformin With Muraglitazar or Pioglitazone in Type 2 Diabetics

Completed · Phase 3

Conditions studied: Type 2 Diabetes

In brief

The purpose of this study is to evaluate if type 2 diabetics who have inadequate glycemic control on metformin alone, have a similar, or not inferior, glycemic response when treated with the combination of muraglitazar and metformin compared to pioglitazone and metformin.

Key facts

Study ID

NCT00240370

Run by

Bristol-Myers Squibb

People needed

1159

Starts

2003-10-01

Last updated by the study team

2010-09-14

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 diabetics
• HbA1c ≥7.0% and ≤10.0%,currently receiving a stable dose of metformin 1500 to 2550 mg/day for at least 6 weeks prior to screening were enrolled in this study.
• Fasting C-peptide ≥1.0 ng/mL
• BMI≤41 kg/m2 mean fasting serum trig. ≤600 g/dL

You may not qualify if…

• symptomatic type 2 diabetics with > 10% weight loss 3 months prior to study
• history of diabetic ketoacidosis, hyperosmolar nonketotic coma, insulin therapy, inability to take muraglitazar, pioglitazone, or metformin according to investigator brochure or labeling
• History of MI (myocardial infarction), coronary angioplasty or bypass graft(s), valvular disease or repair, unstable angina pectoris, transient ischemic attack (TIA), cerebrovascular attack, or cerebrovascular accident (CVA) within 6 months, congestive heart failure (NYHA Class III and IV, uncontrolled hypertension, history of, or renal disease, peripheral vascular disease (PVD), pulmonary disease, gastrointestinal disease, active liver disease or endocrine disease.

Where it is running

• Local Institution — Columbiana, Alabama, United States
• Local Institution — Mesa, Arizona, United States
• Local Institution — Peoria, Arizona, United States
• Local Institution — Carlisle, Arkansas, United States
• Local Institution — Jonesboro, Arkansas, United States
• Local Institution — Little Rock, Arkansas, United States
• Local Institution — Pine Bluff, Arkansas, United States
• Local Institution — Sherwood, Arkansas, United States
• Local Institution — Anaheim, California, United States
• Local Institution — Artesia, California, United States
• Local Institution — Encino, California, United States
• Local Institution — Encintas, California, United States
• Local Institution — Fresno, California, United States
• Local Institution — Long Beach, California, United States
• Local Institution — Los Angeles, California, United States
• Local Institution — Northridge, California, United States
• Local Institution — Denver, Colorado, United States
• Local Institution — Hamden, Connecticut, United States
• Local Institution — Altamonte Springs, Florida, United States
• Local Institution — Hollywood, Florida, United States
• Local Institution — Jacksonville, Florida, United States
• Local Institution — Miami, Florida, United States
• Local Institution — New Port Richie, Florida, United States
• Local Institution — Saint Cloud, Florida, United States
• Local Institution — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.