A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID)

Completed · Phase 3

Conditions studied: Coronary Arteriosclerosis

In brief

The purpose of this study is to see if 40 mg of rosuvastatin taken daily will reduce the atherosclerosis (fatty deposits) in your arteries

Key facts

Study ID

NCT00240318

Run by

AstraZeneca

People needed

450

Starts

2002-11-01

Expected to finish

2005-11-01

Last updated by the study team

2010-11-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical indication for coronary catheterization. Target Coronary Artery: The target vessel must have .50% reduction in lumen diameter by angiographic visual estimation throughout a segment of at least 40 mm in length (the target segment) and the vessel must be large enough to accommodate the IVUS catheter. A lesion of up to 60% is permitted distal to the target segment. Side branches of the target (imaged) vessel may be narrowed up to 70% by visual estimation, provided the target segment contains no lesion greater than 50%.

You may not qualify if…

• Use of lipid-lowering medication for more than 3 months within the previous 12 months. Longer periods of treatment are not permitted because of the potential effects of such therapy on coronary atherosclerosis. Subjects receiving treatment with a lipid-lowering medication within the past 4 weeks require a 4-week wash-out period following which a baseline lipid profile will be taken at visit 2.
• Clinically significant heart disease which, in the opinion of the Principal Investigator (or designee), is likely to require coronary bypass surgery, cardiac transplantation, surgical repair and/or replacement during the course of the study.

Where it is running

• Research Site — Los Angeles, California, United States
• Research Site — San Francisco, California, United States
• Research Site — Santa Rosa, California, United States
• Research Site — Stockton, California, United States
• Research Site — Denver, Colorado, United States
• Research Site — Hartford, Connecticut, United States
• Research Site — Atlantis, Florida, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Maywood, Illinois, United States
• Research Site — Auburn, Maine, United States
• Research Site — Baltimore, Maryland, United States
• Research Site — Ann Arbor, Michigan, United States
• Research Site — Petoskey, Michigan, United States
• Research Site — Minneapolis, Minnesota, United States
• Research Site — Saint Paul, Minnesota, United States
• Research Site — Buffalo, New York, United States
• Research Site — Valhalla, New York, United States
• Research Site — Williamsville, New York, United States
• Research Site — Chapel Hill, North Carolina, United States
• Research Site — Toledo, Ohio, United States
• Research Site — Danville, Pennsylvania, United States
• Research Site — Houston, Texas, United States
• Research Site — Milwaukee, Wisconsin, United States
• Research Site — Auchenflower, Australia
• Research Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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