Prazosin for ETOH or Cocaine Craving

Stopped early · Not applicable · Has a placebo group

Conditions studied: Alcoholism, Cocaine Dependence

In brief

This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-dependent and alcohol-dependent veterans. Both the study medication period and the placebo period are each 4 weeks in duration.

Key facts

Study ID

NCT00240227

Run by

US Department of Veterans Affairs

People needed

8

Starts

2004-04-01

Expected to finish

2009-01-01

Last updated by the study team

2018-08-31

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-70 years
• Current DSM-IV diagnosis of alcohol dependence or cocaine dependence with no use in last 30 days
• Capacity to provide informed consent
• Actively enrolled in chemical dependency treatment at VA Puget Sound English fluency

You may not qualify if…

• Evidence of significant abuse of opiates, PCP, sedatives or anxiolytics
• Suicidal ideation
• DSM IV diagnosis of bipolar mood disorder, schizophrenia or schizoaffective disorder
• Significant acute or chronic medical illness, including unstable angina, recent myocardial infarction, history of congestive heart failure, preexisting hypotension (systolic < 110), or orthostatic hypotension (systolic drop > 20mmHg after two minutes standing or any drop with dizziness), insulin-dependent diabetes mellitus; chronic renal or hepatic failure, pancreatitis, gout, M ni re's disease, benign positional vertigo, narcolepsy
• Concomitant use of alpha-1 antagonists History of prazosin-sensitivity Women who are pregnant, nursing infant(s), or of childbearing potential and not using a contraceptive method judged by the investigator to be effective
• Non-compliance with outpatient chemical dependency treatment

Where it is running

• VA Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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