Prevention of Low Blood Pressure in Persons With Tetraplegia

Completed · Phase 2/Phase 3

Conditions studied: Hypotension, Spinal Cord Injury

In brief

The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while upright in those with tetraplegia. If blood pressure is increased with NOS inhibition in persons with tetraplegia, this would improve our treatment of the condition of low blood pressure during seated postures in individuals with tetraplegia.

Key facts

Study ID

NCT00237770

Run by

US Department of Veterans Affairs

People needed

16

Starts

2003-06-01

Expected to finish

2010-06-01

Last updated by the study team

2014-05-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 65 year olds.
• Non-ambulatory Chronic tetraplegia (1 year after acute SCI).

You may not qualify if…

• central nervous system disease (other than SCI) e.g., multiple sclerosis, amyotrophic lateral sclerosis, syringomyelia, tabes dorsalis;
• peripheral neuropathies;
• surgical sympathectomy;
• coronary heart and/or artery disease;
• anemia;
• hypertension;
• renal function abnormalities;
• diabetes mellitus;
• pituitary insufficiency;
• adrenal insufficiency;
• hypothyroidism; and
• medications known to affect the cardiovascular system.

Where it is running

• VA Medical Center, Bronx — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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