Pilot Study of Terazosin in Treatment of Antidepressant Induced Excessive Sweating

Completed · Not applicable

Conditions studied: Antidepressant Induced Excessive Sweating

In brief

This study is based on the hypothesis that terazosin, a blocker of alpha-1 receptors, will be effective in reducing excessive sweating caused by antidepressant treatment, and will have minimal adverse effects.

Key facts

Study ID

NCT00237510

Run by

Thomas Jefferson University

People needed

15

Starts

2005-05-01

Expected to finish

2007-05-01

Last updated by the study team

2014-03-05

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of a Depressive disorder (Diagnostic and Statistical Manual of Mental Disorders - IV-TR)
• Presence of excessive sweating by self-report
• The excessive sweating started after initiation of an antidepressant and, if treatment with the antidepressant was interrupted, did not persist for more than 4 weeks during that interruption
• Treatment with the antidepressant is deemed to be clinically necessary due to substantial benefit from this antidepressant, and failure to respond to or tolerate an alternative
• Excessive sweating has persisted for at least 4 weeks prior to baseline assessment
• The excessive sweating is rated by the patient as at least moderately bothersome.
• Episodes of excessive sweating occur at least twice a week for last 4 weeks

You may not qualify if…

• Presence of another known disease that could potentially cause excessive sweating
• Failure to respond to antiadrenergic (reducing activity of the sympathetic nervous system) treatment in the past
• Blood pressure less than 110 mm Hg systolic at the screening or baseline visits
• Orthostatic hypotension by history or on assessment at the screening or baseline visits (defined as a decrease of 10 mm Hg or greater after standing for 2 minutes).
• Current antihypertensive treatment
• History of significant cardiac disease, including coronary artery disease
• Current use of phosphodiesterase type 5 inhibitors: sildenafil (Viagra™), tadalafil (CialisTM), or vardenafil (LevitraTM)
• History of priapism (persistent and painful erection)

Where it is running

• Thomas Jefferson University Department of Psychiatry and Human Behavior — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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