Quetiapine Treatment for Post-Traumatic Stress Disorder (PTSD)
Completed · Phase 4 · Has a placebo group
Conditions studied: PTSD
In brief
The purpose of the study is to determine if quetiapine is effective in the treatment of PTSD.
Key facts
- Study ID
- NCT00237393
- Run by
- Ralph H. Johnson VA Medical Center
- People needed
- 80
- Starts
- 2003-08-01
- Expected to finish
- 2007-12-01
- Last updated by the study team
- 2008-02-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female patients 18 years of age or older of any ethnic background meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for PTSD.
- Score of at least 50 on the CAPS-SX at baseline.
- Competent to give informed consent.
- If female, patient should be using a medically approved contraceptive, or not otherwise be of childbearing potential.
- Patients who have not taken medications or herbal remedies for a psychiatric indication within one week prior to the randomized phase.
- Other medications, if any, must have been kept stable for at least one month prior to randomization.
You may not qualify if…
- History of sensitivity to quetiapine
- Use of antipsychotics, antidepressants, or benzodiazepines (except for short-term use during study as specified in Concomitant Medications section) within one week prior to randomization and throughout the study period.
- Medical conditions that may prevent safe administration of quetiapine including clinically significant hepatic, cardiac, or pulmonary disease.
- Medical disorders that may cause or exacerbate anxiety symptoms.
- Alcohol or drug abuse or dependence within one month of study entry as defined by DSM-IV criteria.
- Schizophrenia, schizoaffective disorder, or bipolar disorder.
- Suicidal or homicidal ideation or other clinically significant dangerousness
- Currently seeking compensation or increase in compensation for the effects of the trauma.
- Initiation or change in psychotherapy within 3 months of randomization.
Where it is running
- NM VA Healthcare System — Albuquerque, New Mexico, United States
- Ralph H. Johnson VAMC — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
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