The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.

Completed

Conditions studied: Short Stature, Growth Hormone Deficiency

In brief

This project is designed to answer the question: Is there an acute IGFBP-3 response in normal children? Our specific hypothesis states that under the influence of growth hormone secretagogues, intact IGFBP-3 molecule will undergo proteolysis and liberate IGFBP-3 fragments, along with other components of the ternary complex. This proteolysis will result in measurable rise in IGFBP-3, which will indicate the subject's growth hormone status. Short children with growth hormone deficiency will not show an IGFBP-3 response.

Key facts

Study ID

NCT00235599

Run by

University of Massachusetts, Worcester

People needed

10

Starts

2005-09-01

Expected to finish

2006-10-01

Last updated by the study team

2007-05-17

Who can join

Age: 4 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Bone age < 10 years female, < 12 years male
• Pubertal status: Girls: Tanner I for breast development. Boys: testicular volume of ≤ 3 cc, as measured by the standardized orchidometer (Prader type). The onset of pubic hair development up to and including Tanner III is allowed in the study.
• Adequate nutrition: body mass index ≥ 25th percentile for gender.

You may not qualify if…

• Syndromic short stature
• Chronic illnesses.
• Other disorders, including osteo- or chondrodystrophies, and endocrine causes of short stature such as Cushing syndrome, and untreated hypothyroidism.

Where it is running

• University of Massachusetts Medical School — Worcester, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.