Effects of RG1068 (Secretin) on Information Processing in Schizophrenia

Completed · Phase 2

Conditions studied: Schizophrenia

In brief

The overarching purpose of the proposed study is to determine Secretin's (RG1068) psychophysiological effects on measures of motor learning, affective, and inhibitory information processing in individuals with schizophrenia. Motor learning will be assessed with a classical eye-blink conditioning procedure, requiring the learning of a reflexive eye-blink response to a weak puff of air to the eye.

Key facts

Study ID

NCT00235274

Run by

Indiana University

People needed

30

Starts

2005-11-01

Expected to finish

2006-08-01

Last updated by the study team

2017-03-03

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to give informed consent
• DSM-IV diagnosis of schizophrenia
• 18-55 years of age
• Stable medication > 4 weeks

You may not qualify if…

• Active suicidal ideation
• Concurrent DSM-IV comorbidity with any substance dependence
• A urine drug screen that is qualitatively positive for controlled substances
• Abnormal hepatic function (AST or ALT > 2.5 X the upper limit of normal, or bilirubin > 1.5 X the upper limit of normal)
• Abnormal renal function (BUN or creatinine > 1.5 X the upper limit of normal)
• Abnormal bone marrow function (WBC < 4 x 103/mm3, Platelets <100 x 103/mm3 and hemoglobin <10 g/dl)
• Any history of sensitivity to any of the ingredients in the study drug
• Clinically significant organic disease including cardiovascular, hepatic, pulmonary, neurologic, or renal disease or other medical condition, serious intercurrent illness, or extenuating circumstances that, in the opinion of the Investigator, would interfere with the performance or interpretability of, or put the patient at risk from, the study procedures.
• Women who are pregnant, breastfeeding, or refuse to use adequate birth control

Where it is running

• LaRue Carter Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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