Statin Therapy in Heart Failure: Potential Mechanisms of Benefit

Completed · Phase 4 · Has a placebo group

Conditions studied: Heart Failure, Congestive

In brief

The goal of the investigators' study is to further understand the potentially beneficial effects of statin therapy in patients with heart failure. It is hypothesized that statins will 1) increase the heart's pumping ability 2) improve functioning of the sympathetic nervous system and 3) decrease immune activation in heart failure.

Key facts

Study ID

NCT00233480

Run by

University of California, Los Angeles

People needed

27

Starts

2005-08-01

Expected to finish

2009-02-01

Last updated by the study team

2020-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age≥18 years old
• LVEF ≤ 35%, as documented by echocardiography, radionuclide ventriculography, gated SPECT, or contrast ventriculography within past 6 months
• Symptomatic HF (NYHA II-IV) or current NYHA I with history of symptomatic HF within the last year
• Stable doses of optimal HF medical therapy, unless documented contraindication.

You may not qualify if…

• Ischemic etiology of HF, defined as the presence of at least one of the following four criteria; angiographic evidence of > 50% lesion in 1 or more of the 3 major epicardial vessels; history of myocardial infarction; history of revascularization procedure; evidence of significant perfusion defect in the setting of ischemic symptoms.
• Clinical indication for statin treatment - coronary artery, cerebrovascular, or peripheral vascular disease
• Major cardiovascular event or surgical procedure within past 8 weeks
• LDL<70 mg/dL
• HF secondary to congenital heart disease or uncorrected valvular disease
• Treatment with statin within past 2 months
• Pregnancy
• Contraindication to statin: moderate liver disease, AST/ALT > 150 U/ L, known hypersensitivity
• Likely to receive heart transplant within 3 months
• Known peripheral or autonomic neuropathy

Where it is running

• Ahmanson-UCLA Cardiomyopathy Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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