A Study of the Function of Hormones Present In Taste Buds
Completed
Conditions studied: Diabetes, Obesity, Pre-Diabetes, Metabolic Syndrome
In brief
The purpose of this study is to find out whether the hormones in the taste buds are affected by tasting and eating food, and also whether these hormone levels are affected by an increase in body weight or type 2 diabetes.
Key facts
- Study ID
- NCT00233298
- Run by
- National Institute on Aging (NIA)
- People needed
- 225
- Starts
- 2005-05-26
- Expected to finish
- 2015-01-02
- Last updated by the study team
- 2018-04-05
Who can join
Age: 12 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Pregnancy (pregnancy has been shown to be associated with decrease in insulin sensitivity
- Group A and B subjects cannot have FPG greater than or equal to 100 mg/dl or 2-hr OGTT greater than or equal to 140 mg/dl
- Group D subjects cannot have FPG > 240 mg/dl during the screening visit
- Group D subjects cannot have their morning fasting finger-stick glucose > 240 mg/dl during the 5 days (3 days for glucophage) prior to the visit when their oral hypoglycemic agent(s) are discontinued
- Subjects with type 2 diabetes on insulin therapy
- Hematocrit < 36% for women and < 38% for men
- Peanut allergy
- Presence of other medical conditions that could affect glucose homeostasis
- Use of medications known to impair glucose homeostasis (i.e., amiloride shown to inhibit certain taste responses in hamsters)
- History of liver or renal disease
- History of gastrointestinal or endocrine disorders except for treated hypo- or hyperthyroidism
- Long-term glucocorticoid use (over one month), or other immunosuppressive agents within the past 5 years
Where it is running
- National Institute of Aging, Clinical Research Unit — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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