Study Comparing Immune Response to, and Safety of, Fluviral and Fluzone Influenza Vaccines in Persons 50 y.o. and Over

Completed · Phase 3

Conditions studied: Influenza

In brief

The goal of this study is to determine whether the immune responses induced by Fluviral, the investigational vaccine, are comparable to those induced by Fluzone, which is an influenza vaccine currently licensed in the U.S. The study focuses on persons 50 years old and over. In addition, the study will compare the rate of reactions to the two vaccines, and the general health of persons who receive them over the 42 days after immunization.

Key facts

Study ID

NCT00232947

Run by

ID Biomedical Corporation, Quebec

People needed

900

Starts

2005-10-01

Expected to finish

2006-02-01

Last updated by the study team

2007-01-22

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Stable health status
• Access to a consistent means of telephone contact.
• Comprehension of study requirements, availability for study duration
• Availability and ability to attend scheduled visits
• Females post menopausal, sterile or using accepted contraceptive measures
• Competence to provide informed consent

You may not qualify if…

• Presence of significant acute or chronic medical or neuropsych. illness
• New medical or surgical treatment w/i 1 month
• Change in medication dose due to uncontrolled symptoms w/i 1 month
• Hospitalization w/i 1 month
• Any unusual risk (for age group) of serious adverse events w/i 1 month
• Any neuropsychiatric condition altering competence for consent
• Any neuropsychiatric condition preventing accurate safety reports
• Febrile illness on day of treatment
• Employment in professions at high risk of influenza transmission
• Residence in a long-term-care facility or with an immunocompromised person
• Systolic BP over 150, diastolic over 90, resting pulse under 50 or over 100
• Cancer w/i 3 years
• Immunosuppressive of immunodeficient conditions
• Treatment with systemic glucocorticoids > replacement
• Treatment with cytotoxic or immunosuppressant drugs
• Treatment with immune globulins
• Clotting disorders that increase the risks of intramuscular injections
• History of demyelinating disease or GBS
• Pregnancy or nursing
• Absence of contraceptive practices in women with childbearing potential
• Planned administration of non-influenza vaccines within 30 days
• Receipt of any investigational drug within 30 days
• Receipt of immune globulin treatment within 3 months
• Known or suspected allergy to egg proteins, gelatin, or thimerosal
• History of severe adverse reactions toflu vaccines

Where it is running

• University Clinical Research, Inc. — Pembroke Pines, Florida, United States
• Radiant Research — Atlanta, Georgia, United States
• Radiant Research — Chicago, Illinois, United States
• Vince and Associates Clinical Research — Overland Park, Kansas, United States
• The Center for Pharmaceutical Research — Kansas City, Missouri, United States
• Regional Clinical Research — Endwell, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States
• Radiant Research — Cincinnati, Ohio, United States
• Omega Medical Research — Warwick, Rhode Island, United States
• PI-Coor Clinical Research — Fairfax, Virginia, United States

Full record on ClinicalTrials.gov

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