Estrogen and Perimenopausal Depression

Completed · Phase 4 · Has a placebo group

Conditions studied: Depressive Disorder, Major, Menopause

In brief

During perimenopause (the time just prior to menopause), women often notice many biological, psychological, and social changes. In particular, some women experience depressive symptoms during perimenopause that are severe enough to warrant antidepressant medication. Whether or not women with perimenopausal depression respond to antidepressant medication may depend on the level of estrogen in their blood. This study will investigate whether estrogen will help women who only partially respond to antidepressant medications, as well as examine how different doses of estrogen may affect individuals differently.

Key facts

Study ID

NCT00229450

Run by

University of California, Los Angeles

People needed

17

Starts

2002-04-01

Expected to finish

2004-08-01

Last updated by the study team

2020-02-25

Who can join

Age: 40 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Clinical Diagnosis of Unipolar Major Depression, currently taking antidepressants
• HAM-D between 10 and 17

You may not qualify if…

• History of Psychosis, breast cancer, smoking, dementia, clotting disorders
• Current substance abuse

Where it is running

• UCLA Neuropsychiatric Institute & Hospital — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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