Research on the Nature, Diagnosis, and Treatment of Obesity and Diabetes
Completed
Conditions studied: Insulin Resistance, Obesity
In brief
The purpose of this study is to determine whether the level of FOXA2 expression in fat tissue is a biomarker of insulin resistance. To test this hypothesis, we will perform euglycemic-hyperinsulinemic clamps in normal and obese human subjects to calculate insulin sensitivity, and see if insulin sensitivity correlates with the FOXA2 expression in subcutaneous fat.
Key facts
- Study ID
- NCT00229268
- Run by
- Rockefeller University
- People needed
- 14
- Starts
- 2005-09-01
- Expected to finish
- 2010-04-01
- Last updated by the study team
- 2012-06-01
Who can join
Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy individuals
- Age 21-45 years old
- BMI: either < 25, or 30-35, or > 40
- All patients must be willing and able to sign an informed consent form -
You may not qualify if…
- Chronic illnesses other the than mild forms of illnesses related to obesity, such as hypertension, hyperlipidemia, and others, that do not require medical treatment
- Diabetes mellitus previously diagnosed as per subject report or an abnormal 2 hour OGTT at screening
- Chronic drug treatment for any medical condition
- Active weight reduction of more than 7 pounds in the last 3 months
- History of bleeding or blood clotting disorders
- Subjects with hemoglobin <8.5 gm/dl
- Changes in smoking habits for the last 6 months
- Current pregnancy or current breast-feeding in women
- Allergic reaction to local anesthetics
- History of anaphylaxis or anaphylactic-like reactions
- Tendency to form scars (keloids) easily
- Irregular menses
- HIV and hepatitis B or C positive subjects -
Where it is running
- Rockefeller University Hospital — New York, New York, United States
Full record on ClinicalTrials.gov
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