The Role of Serotonin in Hot Flashes After Breast Cancer

Completed · Not applicable

Conditions studied: Breast Cancer

In brief

The purpose of this proposal is to improve our understanding of the role of tryptophan and serotonin in hot flashes. The main hypothesis is that alterations in tryptophan and serotonin levels are involved in the induction of hot flashes in women with breast cancer and genetic variations in the serotonin receptors and transporters also play a role.

Key facts

Study ID

NCT00228943

Run by

Indiana University

People needed

28

Starts

2005-07-01

Expected to finish

2008-11-01

Last updated by the study team

2015-04-14

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years of age
• Willing and able to provide informed consent
• Reporting daily hot flashes
• Able to read, write, and speak English
• Postmenopausal to limit sample variability (> 12 months amenorrhea)
• Greater then 1 month but < 5 years post-treatment (surgery, radiation, chemotherapy) for non-metastatic breast cancer.
• These criteria allow inclusion of women successfully treated for recurrent breast cancer since there is no known reason to exclude them. Menopausal status is assessed using self-reports due to problems in reliably measuring follicle-stimulating hormone levels and estradiol in tamoxifen users.

You may not qualify if…

• Exclusion criteria are current depression, history of migraines or hepatitis, abnormal chemistry profile (e.g., sodium, potassium, glucose), or a positive urine drug screen for illegal substances.

Where it is running

• Indiana University Cancer Center — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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