Herpesvirus in Idiopathic Pulmonary Fibrosis

Completed

Conditions studied: Lung Diseases, Herpesvirus Infections

In brief

The purpose of this study is to: 1) to develop a method to quantify Epstein Barr Virus (EBV) load in lung tissue of humans and to determine whether EBV viral load is significantly higher in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) than in control lung tissue; 2) to determine whether EBV localized to epithelial cells in IPF lungs and to relate epithelial positivity to tissue viral load; 3) to measure viral load in induced sputum from IPF subjects over time in order to determine whether periodic active herpes virus replication occurred in the respiratory tract; and 4) to compare longitudinal measures of viral load in induced sputum with simultaneously collected saliva in order to assess the clinical utility of the two approaches.

Key facts

Study ID

NCT00228670

Run by

Emory University

People needed

41

Starts

2005-07-01

Expected to finish

2012-08-01

Last updated by the study team

2017-05-11

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Failure of the patient to provide informed consent.

Where it is running

• Emory University — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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