Integrated Treatment for Cocaine and Mood Disorders - 1

Completed · Phase 2

Conditions studied: Cocaine Dependence, Depressive Disorder, Major

In brief

The purpose of this study is to test whether cognitive behavioral therapy and bupropion hydrochloride will help cocaine users, who are depressed, reduce or end their cocaine use and improve their mood.

Key facts

Study ID

NCT00227812

Run by

National Institute on Drug Abuse (NIDA)

People needed

140

Starts

2001-04-01

Expected to finish

2005-12-01

Last updated by the study team

2017-01-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Generally physically healthy
• Aged 18-55
• Meets cocaine dependence by DSM-IV criteria
• Meets major depressive disorder or substance-induced depression disorder by DSM-IV criteria.
• Willing and able to participate in the 12 week treatment study and one year follow up.

You may not qualify if…

• Pregnant or breastfeeding.
• Taking medications that interact with the study medication (MAO inhibitors, anticonvulsants, haloperidol, phenothiazines,selegiline, anesthetics
• Have other psychiatric diagnoses requiring therapy or medication.
• Physically dependent on opiates or alcohol.
• Currently being treated with bupropion hydrochloride (e.g. Zyban).

Where it is running

• University of Texas Health Sci Cntr Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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