TROPHY - Candesartan Cilexetil Long-term Hypertension Prevention Trial

Completed · Phase 3

Conditions studied: Hypertension

In brief

The purpose of this study is to determine the effectiveness of candesartan cilexetil in preventing hypertension in people with high normal blood pressure. Patients will be randomized to either Candesartan or placebo for an initial 2-year period followed by a second 2-year period of placebo for all patients.

Key facts

Study ID

NCT00227318

Run by

AstraZeneca

People needed

1000

Starts

1998-07-01

Expected to finish

2005-10-01

Last updated by the study team

2011-08-30

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects between the ages of 30 and 65 (inclusive) at the time of the informed consent process
• have an average clinic BP in the high normal range of < 139/85-89 mmHg or 130-139/< 89 mm Hg (high normal BP range) (mean systolic and/or diastolic pressure based on 3 consecutive measurements) derived from the average of clinic visits 1,2 and 3.

You may not qualify if…

• Have proteinuria >1 + (by dipstick method)
• have a stroke, myocardial infarction (MI), transient ischemic attack (TIA), the presence of any clinically significant evidence of atherosclerosis or hypertensive target organ involvement or any significant medical condition that may compromise participation in this study.

Where it is running

• Research Site — Mobile, Alabama, United States
• Research Site — Long Beach, California, United States
• Research Site — Redondo Beach, California, United States
• Research Site — Santa Ana, California, United States
• Research Site — Tustin, California, United States
• Research Site — Wilmington, Delaware, United States
• Research Site — Washington D.C., District of Columbia, United States
• Research Site — Bay Pines, Florida, United States
• Research Site — Gainsville, Florida, United States
• Research Site — Ocala, Florida, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Shawnee Mission, Kansas, United States
• Research Site — Chelsea, Michigan, United States
• Research Site — Detroit, Michigan, United States
• Research Site — Minneapolis, Minnesota, United States
• Research Site — Jackson, Mississippi, United States
• Research Site — Florissant, Missouri, United States
• Research Site — Kansas City, Missouri, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Buffalo, New York, United States
• Research Site — Rochester, New York, United States
• Research Site — Williamsville, New York, United States
• Research Site — Asheville, North Carolina, United States
• Research Site — Chapel Hill, North Carolina, United States
• Research Site — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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