Alcohol and Gender Effects on Stress Circuit Function
Completed · Not applicable · Has a placebo group
Conditions studied: Alcoholism, Stress, Alcohol Dependence
In brief
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the differences between men and women in the two recovering alcoholic groups.
Key facts
- Study ID
- NCT00226694
- Run by
- University of Cincinnati
- People needed
- 96
- Starts
- 2003-09-01
- Expected to finish
- 2012-08-01
- Last updated by the study team
- 2014-01-07
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Able to provide written consent.
- Are actively engaged in a recovery program for alcoholism;
- Have a current (within the past 12 months) diagnosis of DSM-IV alcohol dependence in early- (modified to a minimum of 4 months) full remission; and
- Are residing in a controlled sober living environment; and
- Agree to provide at least one collateral informant who knows the subject well and can attest to their sobriety (recovering alcoholics only).
You may not qualify if…
- Have evidence of any clinically significant laboratory evidence of hematologic, hepatic, cardiovascular, renal, pulmonary, thyroid or other endocrine disease;
- Are taking oral contraceptives or other hormonal replacements (e.g., estrogen or progesterone);
- Are pregnant, or planning to become pregnant during the next 9 months;
- Have taken other psychotropic drugs (including SSRIs, MAO inhibitors and other antidepressants, antipsychotics, mood stabilizers, non-benzodiazepine anxiolytics or hypnotics) within 6 weeks of the first laboratory session;
- Have taken any investigational drug within 90 days of the first laboratory session; or
- Are making efforts to quit smoking or have taken any pharmacotherapies for smoking cessation (i.e., bupropion, nicotine-replacement patches or gum; clonidine, buspirone) within 90 days of the first laboratory session.
Where it is running
- The Department of Veterans Affairs / Veterans Healthcare System of Ohio — Cincinnati, Ohio, United States
Full record on ClinicalTrials.gov
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