A Study Measuring Effects on Intima Media Thickness: An Evaluation of Rosuvastatin 40 mg (METEOR)

Completed · Phase 3

Conditions studied: Hypercholesteremia

In brief

The purpose of this trial is to see if rosuvastatin will be effective in decreasing the thickness of the walls of the arteries in the neck for people who already have some evidence of thickening of these walls.

Key facts

Study ID

NCT00225589

Run by

AstraZeneca

People needed

840

Starts

2002-08-01

Expected to finish

2006-05-01

Last updated by the study team

2010-11-19

Who can join

Age: 45 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Maximum IMT >1.2 mm and 3.5 mm at any location in the carotid ultrasound studies conducted at both Visit 2 (Week -4) and Visit 3 (Week -2)
• Subjects with age and no other risk factor: Fasting LDL-C at Visit 1 (Week -6) is >120 mg/dL (3.1mmol/L) and <190 mg/dL (4.9 mmol/L)
• Subjects with 2 or more risk factors and a 10-year coronary heart disease (CHD) risk < 10%: Fasting LDL-C at Visit 1 (Week -6) is >120 mg/dL (3.1 mmol/L) and <160 mg/dL (4.1 mmol/L)

You may not qualify if…

• Use of pharmacologic lipid-lowering medications (eg, HMG-CoA reductase inhibitors, fibrate derivatives, bile acid binding resins, niacin or its analogues at doses >400 mg) within 12 months prior to Visit 1 (Week -6).
• Clinical evidence of coronary artery disease or any other atherosclerotic disease such as angina, MI, TIA, symptomatic carotid artery disease, CVA, CABG, PTCA, peripheral arterial disease, AAA.

Where it is running

• Research Site — La Jolla, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — San Diego, California, United States
• Research Site — Santa Ana, California, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — Brooklyn Center, Minnesota, United States
• Research Site — Minneapolis, Minnesota, United States
• Research Site — Salisbury, North Carolina, United States
• Research Site — Winston-Salem, North Carolina, United States
• Research Site — Cincinnati, Ohio, United States
• Research Site — Glen Mills, Pennsylvania, United States
• Research Site — Philadelphia, Pennsylvania, United States
• Research Site — Pittsburgh, Pennsylvania, United States
• Research Site — Houston, Texas, United States
• Research Site — Kirkland, Washington, United States
• Research Site — Renton, Washington, United States
• Research Site — Seattle, Washington, United States
• Research Site — Madison, Wisconsin, United States
• Research Site — Brussels, Belgium
• Research Site — Brussels (Anderlecht), Belgium
• Research Site — Leuven, Belgium
• Research Site — Prague, Czechia
• Research Site — Slaný, Czechia
• Research Site — Alhambra, California, United States

Full record on ClinicalTrials.gov

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