Gas Kinetics and Metabolism in Anesthesia During Non Steady State

Withdrawn before enrolling

Conditions studied: Anesthetized Healthy Patients (ASA 1 or 2) in the Supine Position, Excluding Head, Neck and Head Surgeries, Anesthetized Patient With Severe Systemic Disease (ASA 3 or 4)

In brief

During clinical anesthesia, it is astonishing that CO2 monitoring consists mainly of end-tidal PCO2 to confirm endotracheal intubation and to estimate ventilation, and O2 monitoring consists of a single PO2 measurement to detect a hypoxic gas mixture. Better understanding of how O2 and CO2 kinetics monitoring can define systems pathophysiology will greatly enhance safety in anesthesia by detecting critical events such as abrupt decrease in cardiac output (Q.T) by vena-caval compression during abdominal surgery, occurrence of CO2 pulmonary embolism during laparoscopy, rising tissue O2 consumption (V.O2) during light anesthesia, and onset of anaerobic metabolism (V.CO2 is disproportionately higher than V.O2).

Key facts

Study ID

NCT00225381

Run by

University of California, Irvine

People needed

0

Starts

2005-08-01

Expected to finish

2012-01-13

Last updated by the study team

2021-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All adult patients at UCIMC who are undergoing anesthesia and surgery are eligible for the studies
• Patients must be American Society of Anesthesiologists (ASA) Class 1 or 2 (generally healthy patients). We plan on studying 100 patients, divided into 5 equally numbered groups. A power analysis of the sample size shows the need for minimum of 20 patients. High risk 3 subgroups (ASA 3), approximately 20 adult patients (included within the 100 planned patients), will be investigated for the (1) RQ correlation with arterial blood gas, (2) for the exercise study and (3) for the esophageal Doppler studies. These study groups include patients that are categorized as ASA 1, 2 or 3, (total of 60 patients) however; the total number of ASA 3 patients will not exceed 20. Subjects having surgeries around the head and neck, as well as surgeries that require the patient to lie face down will be excluded from the study
• Gender and minority status will not be an exclusion factor for any potential study patient

You may not qualify if…

• Cardiovascular:
• Significant vascular disease, especially cardiac and cerebral vascular disease
• Patients will be excluded if they have a history of having a myocardial infarction or cerebral vascular attack
• Significant hypertension (> 170 systolic, > 90 diastolic) (except for the high risk subgroup mentioned before)
• Pulmonary:
• Significant asthma (mild persistent or greater according to the National Asthma Education and Prevention Program classification system) chronic obstructive pulmonary disease (COPD) (Stage II: Moderate COPD according to the Global Initiative for Chronic Obstructive Lung Disease classification
• Worsening airflow limitation, (FEV1 ≤30% ), and usually the progression of symptoms, with shortness of breath typically developing on exertion), bullous lung disease, or raised intra-cranial pressure (except for the high risk subgroup mentioned before)
• Esophageal Doppler:
• If localized pathology is present, including pharyngeal tumor or significant esophageal varices, then the esophageal probe will not be used.
• Emergency cases:
• Excluded from the study. Only elective patients will be enrolled.
• Short surgeries:
• Surgeries that are expected to last 45 minutes or less will be excluded.

Where it is running

• University of California Irvine Medical Center — Orange, California, United States

Full record on ClinicalTrials.gov

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