Pathogenesis of Adverse Drug Reactions

Completed

Conditions studied: Seizures

In brief

The purpose of the study is to examine the individual metabolic profiles of pediatric patients receiving carbamazepine or valproate therapy, in an attempt to determine identities of the reactive metabolites or, alternatively, the identities of those metabolites that serve as potential precursors to reactive species.

Key facts

Study ID

NCT00224952

Run by

Children's Mercy Hospital Kansas City

People needed

274

Starts

2002-07-01

Expected to finish

2010-03-01

Last updated by the study team

2017-08-14

Who can join

Age: 1 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pediatric patients of both genders between 1 and 16 years of age receiving CBZ or VPA mono-therapy will be recruited for this study. Additionally, for those patients who are receiving drugs other than CBZ or VPA to control their seizures, if CBZ or VPA are subsequently added to their treatment regimen, then these patients will also be recruited for this study.

You may not qualify if…

• None

Where it is running

• Kosair Children's Hospital — Louisville, Kentucky, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Primary Children's Hospital, Pediatric Neurology — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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