Maribavir for Prevention of CMV After Stem Cell Transplants

Completed · Phase 2 · Has a placebo group

Conditions studied: Cytomegalovirus Infection

In brief

Cytomegalovirus (CMV) infections remain a significant problem following various types of transplants that are associated with strong immunosuppressive therapy. Maribavir is a new oral anti-CMV drug with a novel mechanism of action compared to currently available anti-CMV drugs. This study will test the safety and anti-CMV activity of different doses of maribavir when given as CMV prophylaxis following stem cell transplants.

Key facts

Study ID

NCT00223925

Run by

Shire

People needed

111

Starts

2004-10-28

Expected to finish

2006-04-05

Last updated by the study team

2021-05-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Allogeneic stem cell transplant recipient
• Recipient CMV seropositive
• Have transplant engraftment
• Able to swallow tablets

You may not qualify if…

• CMV organ disease
• HIV infection
• Use of other anti-CMV therapy post-transplant

Where it is running

• City of Hope Medical Center — Duarte, California, United States
• UCLA Medical Center — Los Angeles, California, United States
• Loyola University — Maywood, Illinois, United States
• Tufts-New England Medical Center — Boston, Massachusetts, United States
• Wayne State Medical Center — Detroit, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Memorial Sloan-Kettering Cancer Center — New York, New York, United States
• Duke Medical Center — Durham, North Carolina, United States
• Baylor University Medical Center — Dallas, Texas, United States
• MD Anderson Cancer Center — Houston, Texas, United States
• University of Utah — Salt Lake City, Utah, United States
• Fred Hutchinson Cancer Research Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.