Motor Learning in Gait in Subjects With Diabetic Peripheral Neuropathy

Completed · Not applicable

Conditions studied: Diabetes, Peripheral Neuropathy

In brief

The purpose of this study is to determine whether individuals with diabetic peripheral neuropathy can learn to change the way they walk in order to reduce the pressures underneath the feet, which may lead to a reduced risk of foot ulceration.

Key facts

Study ID

NCT00223782

Run by

US Department of Veterans Affairs

People needed

150

Starts

2004-05-01

Expected to finish

2006-09-01

Last updated by the study team

2008-03-24

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of diabetes for at least one year.
• Diabetic peripheral neuropathy as defined by failure to sense the 5.07 (10g) monofilament test in one or more of the six sites tested (31;32)
• Age 50-80 years old
• Able to ambulate independently without assistive devices (e.g. walker or crutches) (8) for 30 feet.
• No evidence of neurological (other than peripheral neuropathy) or orthopedic conditions

You may not qualify if…

• Other non-diabetic causes of neuropathy by history
• Symptomatic peripheral vascular disease
• Joint pain, swelling and/or limited of range of motion in the lower extremities that interfere with walking or exercise
• Visual problems not correctable with glasses or contact lens
• Passive range of motion limitations are described as:
• Hip flexion < 1000;
• Hip extension < 200;
• Knee flexion < 1250;
• Knee extension < 00 (unable to obtain full extension);
• Ankle plantar flexion < 250;
• Ankle dorsiflexion < 150
• Other systemic or local diseases that could interfere with walking assessment
• Severe systemic diseases other than diabetes or its complications, especially those interfering with exercise tolerance
• Amputation in the lower extremities
• Terminal illness
• Severe obesity: BMI>30 kg/m2 (33)
• Severe foot deformities (e.g. flexion contracture of the toes, pes cavus, Charcot disease)
• Mini-mental status of <27 or diagnosis of dementia
• History of alcohol or drug abuse

Where it is running

• VA Greater Los Angeles Healthcare System, West LA — West Los Angeles, California, United States

Full record on ClinicalTrials.gov

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