Treatment of Orthostatic Hypotension in Autonomic Failure

Completed · Phase 1 · Has a placebo group

Conditions studied: Autonomic Failure, Orthostatic Hypotension

In brief

The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.

Key facts

Study ID

NCT00223691

Run by

Vanderbilt University

People needed

389

Starts

2002-03-01

Expected to finish

2017-01-01

Last updated by the study team

2017-01-18

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients referred for evaluation of their autonomic function
• Ages 18-85

You may not qualify if…

• Pregnancy

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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