Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence

Completed · Phase 4 · Has a placebo group

Conditions studied: Bipolar Disorder, Alcohol Abuse/Dependence

In brief

The abuse of alcohol is especially common in people with bipolar disorder. However, very little is known about the pharmacotherapy of people with both bipolar disorder and alcohol abuse/dependence. The purpose of this study is to determine if alcohol use and cravings are decreased with quetiapine add-on therapy compared to placebo and to determine if quetiapine add-on therapy is associated with greater improvement in mood, impulsivity, functioning and decreased alcohol use than placebo.

Key facts

Study ID

NCT00223249

Run by

University of Texas Southwestern Medical Center

People needed

115

Starts

2002-11-01

Expected to finish

2004-08-01

Last updated by the study team

2016-04-04

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Bipolar I or II
• Ages 18-70

You may not qualify if…

• Life threatening medical condition causing participation in the study hazardous
• Alcohol abuse within the past 2 weeks
• History of cataracts or likely cataracts on baseline eye exam
• History of hepatic cirrhosis or AST or ALT more than three times normal limit
• Current active suicidal or homicidal ideation
• History of allergic reaction, poor response or intolerable side effects to quetiapine
• Antipsychotic use within 7 days of beginning quetiapine therapy
• Mental retardation, dementia or other severe cognitive impairment

Where it is running

• The UT Southwestern Medical Center at Dallas — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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